PrisTINE Technology is a cutting-edge, non-enzymatic, non-detergent process developed in collaboration with the prestigious Sree Chitra Tirunal Institute for Medical Science and Technology (SCTIMST). This patented technology preserves the natural structural and functional properties of the extracellular matrix (ECM), ensuring superior healing outcomes. Through PrisTINE, we offer patients a ground-breaking solution that accelerates wound healing while minimizing the risk of complications.
Unlike traditional methods, PrisTINE does not rely on enzymes or detergents, which can damage the delicate ECM. This preserves the natural structure, ensuring the highest quality ECM for wound healing.
Benefit: The natural ECM is maintained, promoting optimal regeneration and minimizing rejection by the body.
The ECM plays a crucial role in wound healing by providing structural support and guiding cell migration. PrisTINE ensures that the ECM remains intact, enabling faster and more effective wound healing.
Benefit: CholeDerm® offers an unmatched advantage with its higher biomolecule content and lower DNA levels, ensuring optimal wound healing and reduced immunogenicity.
CholeDerm® contains many proteins that are also present in the human dermis. These proteins serve similar functions in ECM organisation, cell adhesion, migration, and wound healing.
| Important Proteins | Human Dermis | CholeDerm® | Similarity |
|---|---|---|---|
| Collagen |  | | Structural integrity and wound healing |
| Fibronectin | | | Cell adhesion and wound healing |
| Lumican | | | ECM organisation and repair |
| Mimecan (Osteoglycin) | | | ECM structure and healing |
| Decorin | | | Collagen formation and repair |
| TGF-β (Transforming Growth Factor) | | | ECM remodelling and healing |
| Vimentin, Desmin, Actin | | | Structural support and healing |
| Galectin-3 | | | ECM remodelling and cell migration |
| Periostin | | | ECM integrity and repair |
| Alpha-2-HS-glycoprotein (Fetuin-A) | | | ECM regulation and repair |
| Antithrombin-III | | | Anticoagulant and anti-inflammatory |
Developed in collaboration with SCTIMST and validated through rigorous testing, PrisTINE Technology is backed by scientific research and clinical studies, ensuring its effectiveness and safety.
Benefit: Patients and healthcare providers can trust the technology’s reliability and proven results.
Copyright 2014, Mary Ann Liebert, Inc.
Chronic wounds fail to progress through the normal healing stages due to persistent inflammation, impaired cell regeneration, and insufficient ECM remodelling.
CholeDerm® addresses these challenges by promoting faster healing, improving angiogenesis, and enhancing structural integrity through its unique mechanism of action.
How CholeDerm® Promotes Faster and More Effective Wound Healing?
CholeDerm® utilizes a powerful extracellular matrix derived from porcine cholecyst tissue, designed to accelerate the healing of chronic wounds.
Explore the graph and table below to see how CholeDerm® supports healing at every phase, backed by scientific evidence and clinical outcomes.
| Claim | Supporting Study | Key Findings | Citation |
|---|---|---|---|
| Claim 1: High concentration of biomolecules (collagen, elastin, etc.) | Anilkumar TV, Vineetha VP, Revi D, Muhamed J, Rajan A. Biomaterial properties of cholecyst-derived scaffold. J Biomed Mater Res Part B. 2014. | Faster wound healing compared to other ECM-derived products. | Anilkumar TV, Vineetha VP, Revi D, Muhamed J, Rajan A. (2014). J Biomed Mater Res Part B, 102B: 1506-1516. |
| Claim 2: Unique protein profile with 154 proteins | Muhamed J, Rajan A, Surendran A, et al. Comparative profiling of extractable proteins. J Biomed Mater Res B Appl Biomater. 2017. | Reduced immunogenicity and enhanced histocompatibility. | Muhamed J, Rajan A, Surendran A, et al. (2017). J Biomed Mater Res B Appl Biomater, 105(3): 489-496 |
| Claim 3: Lower DNA content for improved graft acceptance | Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV. Biocompatibility of a porcine cholecyst-derived scaffold. Toxicologic Pathology. 2015. | Higher safety profile in clinical use with no adverse reactions. | Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV. (2015). Toxicologic Pathology, 43(4): 536-545. |
| Claim 4: Fewer immunogenic molecules, reducing graft rejection | Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV. Biocompatibility and Immunophenotypic Characterization of Cholecyst-Scaffold. Toxicologic Pathology. 2015. | Reduced risk of graft rejection compared to other ECM products. | Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV. (2015). Toxicologic Pathology, 43(4): 536-545. |
| Claim 5: Lower WVTR, promoting moisture retention | Revi D, Vineetha VP, Muhamed J, Rajan A, Anilkumar TV. Porcine cholecyst-derived scaffold promotes wound healing. J Tissue Eng. 2013. | Better moisture retention for optimal wound healing environment. | Revi D, Vineetha VP, Muhamed J, Rajan A, Anilkumar TV. (2013). J Tissue Eng, 4: 2041731413518060. |
Our innovative products are backed by rigorous scientific research, ensuring the highest quality and effectiveness. Below are key studies related to our products and their applications in advanced wound care
| Publication Title | Journal | Year | Authors | Key Findings / Relevance |
|---|---|---|---|---|
| Biomaterial properties of cholecystderived scaffold recovered by a nondetergent/enzymatic method | Journal of Biomedical Materials Research Part B: Applied Biomaterials | 2014 | Thapasimuthu V. Anilkumar et al. | A novel method for preparing CholeDerm® scaffolds was demonstrated. A non-enzymatic, non-detergent scaffold retained ECM properties similar to those of a commercial small intestinal submucosa and promoted effective wound healing in a rabbit model, indicating potential applications for hollow organ scaffolds. |
| Porcine cholecyst–derived scaffold promotes full-thickness wound healing in rabbit | Journal of Tissue Engineering | 2014 | Deepa Revi et al. | This study assessed the properties of CholeDerm®, a porcine cholecyst-derived scaffold, and its application for full-thickness wound healing in rabbits. The scaffold was rich in biomolecules like elastin and glycosaminoglycans, promoting rapid cell proliferation in the early phases and effective collagen deposition during the remodelling phases. Thus, it is a promising graft material for skin repair. |
| Comparative local immunogenic potential of scaffolds prepared from porcine cholecyst, jejunum, and urinary bladder in rat subcutaneous model | Journal of Biomedical Materials Research Part B: Applied Biomaterials | 2014 | Jaseer Muhamed et al. | This study compared the immunogenic response of CholeDerm® with jejunum and urinary bladder scaffolds in rats. The CholeDerm scaffold elicited lower immunogenicity and favourable graft-acceptance reactions, making it a better candidate for xenografts than the jejunum and urinary bladderderived scaffolds. |
| Comparative profiling of extractable proteins in extracellular matrices of porcine cholecyst and jejunum intended for preparation of tissue engineering scaffolds | Journal of Biomedical Materials Research Part B: Applied Biomaterials | 2017 | Jaseer Muhamed et al. | This study identified 154 proteins in CholeDerm® and 186 proteins in the jejunum-derived scaffold (JDE). CholeDerm contained fewer cellular proteins and histocompatibility antigens than JDE, suggesting that protein composition differences could account for the varied immunological and wound healing responses. |
| Biocompatibility and Immunophenotypic Characterization of a Porcine Cholecyst–derived Scaffold Implanted in Rats | Toxicologic Pathology | 2015 | Jaseer Muhamed et al. | The CholeDerm®'s biocompatibility in a rat model was demonstrated, revealing its differential local immune response compared to reference material. This supports the safe use of CDS as a xenograft. |
| A Porcine-Cholecyst-Derived Scaffold for Treating Full Thickness Lacerated Skin Wounds in Dogs | Veterinary Research Communications | 2018 | Satheesan Karthika et al. | Evaluated CholeDerm® for full-thickness skin wounds in dogs. It showed significantly faster healing than a commercial-grade bovine dermal collagen scaffold, demonstrating its effectiveness as a wound-healing bio scaffold. |
| Gelatin-Modified Cholecyst-Derived Scaffold Promotes Angiogenesis and Faster Healing of Diabetic Wounds | ACS Applied Bio Materials | 2021 | Manjula P. Mony et al. | Both gelatin-modified CholeDerm® and non-modified CholeDerm® demonstrated promising results in enhancing angiogenesis and accelerating healing in diabetic wounds. However, the gelatin-modified version exhibited a slightly superior performance. |
Click here to download a preclinical evidence compendium.
Claim: CholeDerm® produces more Alpha-Smooth Muscle Actin (ASMA) positive cells during the early inflammatory phase, helping to stimulate wound contraction and ECM deposition.
Supporting Data:
“Revi D, Vineetha VP, Muhamed J, et al. (2013). Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbits. Journal of Tissue Engineering.”
Claim1: CholeDerm® promotes epidermal cell proliferation, contributing to tissue regeneration and faster healing.
Supporting Data:
“Revi D, Vineetha VP, Muhamed J, et al. (2013). Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbits. Journal of Tissue Engineering.”
Claim2: CholeDerm® promotes angiogenesis through M2 macrophages, which release angiogenic factors to support tissue healing.
Supporting Data:
“Mony MP, Shenoy SJ, Raj R, et al. (2021). Gelatin-Modified Cholecyst-Derived Scaffold Promotes Angiogenesis and Faster Healing of Diabetic Wounds. ACS Applied Bio Materials.
Claim1: CholeDerm® stimulates higher cell remodeling during the remodeling phase, improving the wound’s final structure and integrity.
Supporting Data:
“Revi D, Vineetha VP, Muhamed J, et al. (2013). Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbits. Journal of Tissue Engineering.”
Claim2: CholeDerm® induces Type I collagen formation, improving tensile strength in grafted skin.
Supporting Data:
“Revi D, Vineetha VP, Muhamed J, et al. (2013). Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbits. Journal of Tissue Engineering.
Access to this page is restricted to healthcare professionals to ensure that medical information is provided to the appropriate audience.
The details collected are solely for professional engagement and will not be shared or used for any other purpose.
